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KMID : 0617319910010010119
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Journal of Pharmacetical Sceiences Ewha Womans University
1991 Volume.1 No. 1 p.119 ~ p.129
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Dissolution of Promethazine·HCl from the Coprecipitate with Gel forming Excipients
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Abstract
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The coprecipitates of promethazine hydrochloride, a cationic water-soluble as a model drug used drug, with pectin, chondroitin-Na-sulfate and sodium alginate, the gel forming excipients, were studied to determine their dissolution profiles in distilled water and 0.1N HCI medium by means of the KP dissolution method.
The dissolution rates of the coprecipitate tablets were very slow, especially promethazine-alginate coprecipitate tablet in comparison with the intact drug, suggesting that it may be useful for sustained-release preparations.
The formation of the coprecipitates was conformed by powder X-ray diffractometry.
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